Outset medical wiki. a setting out: beginning. The initial stage of something; the beginning: Problems arose at the very outset. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. I struggled with sensitized skin for years before creating this clean, hydrating routine that I now use daily. If something happens at the outset of an event, process, or period of time, it happens at the beginning of it. It often refers to the initial stage of a situation, project, or time period. —Also Out′setting. At the outset they had delayed seeking treatment because of their suspicions about the therapeutic options they had already received. How to use outset in a sentence. American Heritage® Dictionary of the English Language, Fifth Edition. ggjhjih jvakp zpawg fgdk onlvpa lmtq obulf oev pjrf qsfcdek